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Advances in Research on Neurodegeneration: Volume 6 by Margot Mayer-Pröschel (auth.), Prof. Dr. W. Poewe, Dr. G.

By Margot Mayer-Pröschel (auth.), Prof. Dr. W. Poewe, Dr. G. Ransmayr (eds.)

The publication includes unique articles and stories awarded on the sixth overseas iciness convention on Neurodegeneration, held from November 20–23, 1997 in Kitzbuhel/Austria. the purpose of this convention was once to give and speak about contemporary information at the interface among neuroimmunology and neurodegeneration, particularly susceptibility to autoimmune and neurodegenerative techniques, neuroprotection and restorative remedy suggestions. those matters have been mentioned within the mild of modern advancements in a number of sclerosis, Parkinson’s disorder, amyotrophic lateral sclerosis, Huntington’s ailment and multisystem atrophy. The articles spotlight issues, that are fairly fascinating for the clinician and the neuroscientist. many of the neuroprotective thoughts have already been constructed or are at this time clinically investigated. The neuroprotective position of deep mind stimulation, antiglutamatergic treatment and apomorphine should be established in medical experiences within the close to destiny. this can be additionally the case for destiny healing ways to recovery of the broken worried process, corresponding to somatic gene treatment, implantation of genetically converted cell-lines and medically managed and directed improvement of embryonic cells. The convention highlighted the position of the glia, which turns out to play a key function, either in generally as neuroimmunological and neurodegenerative issues categorised ailments, as indicated above. the themes mentioned within the booklet are major for contemporary advancements in scientific neurology and neuroscience, as proven within the present literature and at foreign congresses.

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The development of the "newer" dopamine agonists offered a good opportunity to design and conduct more convincing and appropriate trials than the previous available ones, to assess the true place of dopamine agonists in the treatment of the early stages of the disease. This was particularly interesting because it is still commonly beleived that dopamine agonists can only be maintained as monotherapy in a very small proportion of patients after 2 to 3 years of treatment (less than 5% according to several authors) and that they often induce unacceptable severe psychiatric side effects which markedly reduce their benefit/risk ratio in clinical practice.

It should also be emphasized that crossreactivity is likely to be a normal phenomenon in immune recognition, and may not explain the occurrence of autoimmune diseases by itself. It remains to be proven that an infection is an effective trigger in vivo for self reactive T cells that are part of the normal T cell repertoire. References Alberola-Ila J, Takaki S, Kerner JD, Perlmutter RM (1997) Differential signaling by lymphocyte antigen receptors. Annu Rev Immunol15: 125-154 Barnaba V, Sinigaglia F (1997) Molecular mimicry and T cell-mediated autoimmune disease.

A similar study is presently on-going to compare ropinirole and levodopa. Clinical trials to assess putative neuroprotective effects are also on going with ropinirole and pramipexole. Up to now, the available clinical controlled data suggest that the newer dopamine agonists have very similar clinical effects with only minor superiority, if any, versus bromocriptine. Introduction Over the past 40 years, few topics in clinical neuropharmacology have surpassed Parkinson's disease regarding our progresses in understanding the pathophysiological mechanisms of the disease and our pharmacological 34 o.

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