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Advances in Pharmacological Research and Practice. by J. Knoll and K. Kelemen (Eds.)

By J. Knoll and K. Kelemen (Eds.)

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Extra resources for Advances in Pharmacological Research and Practice. Proceedings of the 4th Congress of the Hungarian Pharmacological Society, Budapest, 1985

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247-251. , Takáts I. : On the late antiischemic action of the stable Pgl2 analogue: 7-oxo-Pgl2-Na and its possible mode of action. Biochim. : The effect of non-steroidal antiinflammatory drugs and of a linoleic acid-rich diet on early arrhythmias resulting from myocardial ischaemia. In: Early Arrhythmias Resulting from Myocardial Ischaemia. J. / Macmillan Press Ltd. : Uptake and tissue content of fatty acids in dog myocardium un­ der normoxic and ischemic conditions. Res. : Myocardial metabolism and performance during sodium salicylate infusion in dogs.

The simultaneous effects of focal ischaemia and catecholamine release could create a deleterious feedback loop. Local catecholamine release will promote glycogenolysis, ele­ vate intracellular cyclic AMP, and promote slow inward calcium currents, factors all predisposing to VF. Ischaemia, even in the absence of catecholamines, causes a rapid increase in extracellular K"^", a fall in intracellular pH, and a subsequent rise in lactate formation /Fitzgerald 1984/. The electrophysiological sequelae are depressed action poten­ tial duration /APD/, depression of excitability and conduction, leading to electrical disorganisation of the ventricle and ventricular fibrillation.

38:73-82. , Kanaide,H,, Yoshimura,M. , 1981, A protective effect of coenzyme on ischemia and reperfusion of the isolated perfused rat heart. Cardiol. 13:65-74. , 1980, Myocardial infarct size. Part 1. Basic considerations. Heart J. 100:355-372. , 1980, Myocardial infarct size. Part 2. Comparison of anti-infarct effects of beta-blockade, glucose-insulin-potassium, nitrates, and hyaluronidase. Heart J. 100:531-552. , Meo,F. , 1984, Beneficial effects of 1-camitine in the reduction of the necrotic area in acute myocardial infarction.

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