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Advances in Growth Hormone and Growth Factor Research by J. S. Parks, M. Kassels, M. C. McKean, J. T. Parks, C.

By J. S. Parks, M. Kassels, M. C. McKean, J. T. Parks, C. Johnson, L. Meacham (auth.), Eugenio E. MÜller, Daniela Cocchi, Vittorio Locatelli (eds.)

Readers of this ebook can replace their wisdom within the fast-moving box of endocrinology and neurobiology. themes bearing on development and improvement are widely reviewed from either uncomplicated technological know-how and scientific viewpoints. facets with regards to progress improvement and to the keep an eye on of mobile differentiation and multiplication are mentioned. additional new info is supplied on: man made recombinant human progress hormone (rHGH); capability diagnostic and healing functions of the neuropeptide, progress hormone freeing hormone (GHRH); the body structure and physiopathology of the neural keep an eye on of progress hormone secretion; the analysis and treatment of development hormone deficiency or extra states; and the biology, functionality and attainable usage of development elements. those very important new findings are appropriate to growth in pediatrics, pediatric and scientific endocrinology, neuroendocrinology and physiology.

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Cattini PA, Peritz LN, Anderson TR, Baxter JD, Eberhardt NL (1986) The 5' flanking sequences of the human growth hormone gene contain a cell-specific control element. DNA 5: 503-509 Chakravarti A, Phillips JA III, Mellits KH, Buetow KH, Seeburg PH (1984) Patterns of polymorphism and linkage disequilibrium suggest independent origins of the human growth hormone gene cluster. Proc Natl Acad Sci USA, 81: 6085-6089 Chien Y, Thompson EB (1980) Genomic organization of rat prolactin and growth hormone genes.

PARKS, M. KAssELS, M. C. McKEAN, J. T. PARKS, C. JoHNSON and L. A. INTRODUCTION Within the past 10 years, molecular genetic techniques have yielded a wealth of new information about growth hormones (GHs), prolactins, and placental lactogens (Pls). Cloned eDNA copies of messenger RNAs permit sequence comparisons of related peptide hormones within and between species. Genomic clones reveal details of gene structure and, in some cases, disclose clusters of duplicated genes. The purpose of this review is to summarize recent findings about this large family of hormone genes, with special emphasis upon evolution of the human GH and chorionic somatomammotropin (CS) gene cluster.

1975) in some samples. Quantitation of tryptophan was achieved by addition of thioglycolic acid to the samples during 24-h acid hydrolysis (Matsubara and Sasaki 1969). 1% sodium dodecyl sulfate (SDS). 05 mg/ml respectively. Digestion was carried out at ambient temperature and was halted by the addition of four volumes of 2M acetic acid at 100°C, with incubation at that temperature for 10 min. 3, and applied to the Beckman 890 C spinning cup sequencer. 1 M Quadrol program) were run and analyzed as previously described (Rodriguez et al.

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